S100 Family: 2.60.40.720.1.1.2.11

Molscript image for 2ac0C00
Representative domain: 2ac0C00
PDB coordinates for domain 2ac0C00

Classification Lineage (2.60.40.720.1.1.2.11)

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.60 Sandwich
2.60.40 Immunoglobulin-like
2.60.40.720 Gene3D
2.60.40.720.1
2.60.40.720.1.1
2.60.40.720.1.1.2
2.60.40.720.1.1.2.11

Summary of Non-Redundant Representatives

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S100 Count Entries in S100 Family 2.60.40.720.1.1.2.11 (28)

CATH Level CATH code Domain ID Keywords Thumbnail
2.60.40.720.1.1.2.11.1 2ac0C00 Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, cell aging, Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, nucleolus, nucleotide-excision repair, cell cycle arrest, transcription factor binding, insoluble fraction, Neurotrophin signaling pathway, Melanoma, transcription activator activity, Wnt signaling pathway, protein N-terminus binding, response to gamma radiation, Homo sapiens, chromatin binding, Pancreatic cancer, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, mitochondrion, negative regulation of helicase activity, copper ion binding, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, protein complex, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, promoter binding, base-excision repair, Basal cell carcinoma, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis Molscript image for 2ac0C00
2.60.40.720.1.1.2.11.2 2ahiC00 p53 signaling pathway, Huntington's disease, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, cell aging, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, Melanoma, Neurotrophin signaling pathway, cell cycle arrest, nucleotide-excision repair, nucleolus, transcription factor binding, insoluble fraction, Wnt signaling pathway, transcription activator activity, Homo sapiens, chromatin binding, Pancreatic cancer, protein N-terminus binding, response to gamma radiation, mitochondrion, negative regulation of helicase activity, copper ion binding, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, protein complex, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, promoter binding, Basal cell carcinoma, base-excision repair, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding Molscript image for 2ahiC00
2.60.40.720.1.1.2.11.3 2ac0B00 Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, cell aging, response to gamma radiation, protein N-terminus binding, Homo sapiens, chromatin binding, Pancreatic cancer, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Cellular tumor antigen p53, mitochondrion, negative regulation of helicase activity, copper ion binding, nucleotide-excision repair, cell cycle arrest, nucleolus, insoluble fraction, transcription factor binding, Neurotrophin signaling pathway, Melanoma, transcription activator activity, Wnt signaling pathway, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, protein complex, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, promoter binding, base-excision repair, Basal cell carcinoma Molscript image for 2ac0B00
2.60.40.720.1.1.2.11.4 2ac0D00 base-excision repair, Basal cell carcinoma, promoter binding, ATP binding, Thyroid cancer, Apoptosis, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, protein complex, Non-small cell lung cancer, negative regulation of cell growth, Colorectal cancer, Chronic myeloid leukemia, DNA strand annealing activity, protein heterodimerization activity, activation of caspase activity by cytochrome c, ER overload response, nuclear matrix, cellular response to glucose starvation, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, transcription activator activity, Wnt signaling pathway, transcription factor binding, insoluble fraction, nucleolus, nucleotide-excision repair, cell cycle arrest, Melanoma, Neurotrophin signaling pathway, Cellular tumor antigen p53, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, copper ion binding, negative regulation of helicase activity, mitochondrion, response to gamma radiation, protein N-terminus binding, Pancreatic cancer, Homo sapiens, chromatin binding, cell aging, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Huntington's disease, p53 signaling pathway, chaperone binding, MAPK signaling pathway, Cell cycle, enzyme binding, Small cell lung cancer, protein tetramerization, Amyotrophic lateral sclerosis (ALS), tumor protein p53, Prostate cancer Molscript image for 2ac0D00
2.60.40.720.1.1.2.11.5 2ahiD00 protein heterodimerization activity, activation of caspase activity by cytochrome c, ER overload response, nuclear matrix, cellular response to glucose starvation, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, protein complex, Non-small cell lung cancer, negative regulation of cell growth, Colorectal cancer, Chronic myeloid leukemia, DNA strand annealing activity, ATP binding, Thyroid cancer, Apoptosis, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, base-excision repair, Basal cell carcinoma, promoter binding, chaperone binding, MAPK signaling pathway, Cell cycle, enzyme binding, Small cell lung cancer, protein tetramerization, Amyotrophic lateral sclerosis (ALS), tumor protein p53, Prostate cancer, cell aging, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Huntington's disease, p53 signaling pathway, Cellular tumor antigen p53, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, negative regulation of helicase activity, copper ion binding, mitochondrion, protein N-terminus binding, response to gamma radiation, Pancreatic cancer, Homo sapiens, chromatin binding, transcription activator activity, Wnt signaling pathway, insoluble fraction, transcription factor binding, nucleolus, cell cycle arrest, nucleotide-excision repair, Neurotrophin signaling pathway, Melanoma Molscript image for 2ahiD00
2.60.40.720.1.1.2.11.6 2ac0A00 tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, p53 signaling pathway, Huntington's disease, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, cell aging, Homo sapiens, chromatin binding, Pancreatic cancer, response to gamma radiation, protein N-terminus binding, mitochondrion, negative regulation of helicase activity, copper ion binding, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, Neurotrophin signaling pathway, Melanoma, nucleotide-excision repair, nucleolus, cell cycle arrest, transcription factor binding, insoluble fraction, Wnt signaling pathway, transcription activator activity, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, protein complex, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, promoter binding, Basal cell carcinoma, base-excision repair Molscript image for 2ac0A00
2.60.40.720.1.1.2.11.7 2ahiB00 ATP binding, Thyroid cancer, Apoptosis, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, base-excision repair, Basal cell carcinoma, promoter binding, protein heterodimerization activity, activation of caspase activity by cytochrome c, ER overload response, nuclear matrix, cellular response to glucose starvation, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, protein complex, Non-small cell lung cancer, negative regulation of cell growth, Colorectal cancer, Chronic myeloid leukemia, DNA strand annealing activity, Cellular tumor antigen p53, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, copper ion binding, negative regulation of helicase activity, mitochondrion, response to gamma radiation, protein N-terminus binding, Pancreatic cancer, Homo sapiens, chromatin binding, transcription activator activity, Wnt signaling pathway, insoluble fraction, transcription factor binding, nucleotide-excision repair, nucleolus, cell cycle arrest, Neurotrophin signaling pathway, Melanoma, chaperone binding, MAPK signaling pathway, Cell cycle, enzyme binding, Small cell lung cancer, protein tetramerization, Amyotrophic lateral sclerosis (ALS), tumor protein p53, Prostate cancer, cell aging, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Huntington's disease, p53 signaling pathway Molscript image for 2ahiB00
2.60.40.720.1.1.2.11.8 2ahiA00 response to gamma radiation, protein N-terminus binding, Homo sapiens, chromatin binding, Pancreatic cancer, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, mitochondrion, negative regulation of helicase activity, copper ion binding, nucleotide-excision repair, cell cycle arrest, nucleolus, insoluble fraction, transcription factor binding, Neurotrophin signaling pathway, Melanoma, transcription activator activity, Wnt signaling pathway, Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, cell aging, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, promoter binding, base-excision repair, Basal cell carcinoma, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, protein complex Molscript image for 2ahiA00
2.60.40.720.1.1.2.11.9 2ocjA00 nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, protein complex, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Basal cell carcinoma, base-excision repair, promoter binding, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, cell aging, p53 signaling pathway, Huntington's disease, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, mitochondrion, copper ion binding, negative regulation of helicase activity, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, Homo sapiens, chromatin binding, Pancreatic cancer, protein N-terminus binding, response to gamma radiation, Wnt signaling pathway, transcription activator activity, Melanoma, Neurotrophin signaling pathway, nucleotide-excision repair, cell cycle arrest, nucleolus, transcription factor binding, insoluble fraction Molscript image for 2ocjA00
2.60.40.720.1.1.2.11.10 2ocjB00 Small cell lung cancer, protein tetramerization, Amyotrophic lateral sclerosis (ALS), tumor protein p53, Prostate cancer, chaperone binding, MAPK signaling pathway, Cell cycle, enzyme binding, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Huntington's disease, p53 signaling pathway, cell aging, response to gamma radiation, protein N-terminus binding, Pancreatic cancer, Homo sapiens, chromatin binding, Cellular tumor antigen p53, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, negative regulation of helicase activity, copper ion binding, mitochondrion, transcription factor binding, insoluble fraction, nucleolus, cell cycle arrest, nucleotide-excision repair, Neurotrophin signaling pathway, Melanoma, transcription activator activity, Wnt signaling pathway, cellular response to glucose starvation, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, protein heterodimerization activity, activation of caspase activity by cytochrome c, ER overload response, nuclear matrix, Non-small cell lung cancer, negative regulation of cell growth, Colorectal cancer, Chronic myeloid leukemia, DNA strand annealing activity, protein complex, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, ATP binding, Thyroid cancer, Apoptosis, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, promoter binding, base-excision repair, Basal cell carcinoma Molscript image for 2ocjB00
2.60.40.720.1.1.2.11.11 2ocjC00 chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), cell aging, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Cellular tumor antigen p53, mitochondrion, copper ion binding, negative regulation of helicase activity, protein N-terminus binding, response to gamma radiation, Homo sapiens, chromatin binding, Pancreatic cancer, transcription activator activity, Wnt signaling pathway, nucleolus, cell cycle arrest, nucleotide-excision repair, insoluble fraction, transcription factor binding, Melanoma, Neurotrophin signaling pathway, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, protein complex, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, base-excision repair, Basal cell carcinoma, promoter binding Molscript image for 2ocjC00
2.60.40.720.1.1.2.11.12 2ocjD00 Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Apoptosis, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, ATP binding, Thyroid cancer, promoter binding, Basal cell carcinoma, base-excision repair, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, cellular response to glucose starvation, zinc ion binding, ER overload response, nuclear matrix, protein heterodimerization activity, activation of caspase activity by cytochrome c, Colorectal cancer, Chronic myeloid leukemia, DNA strand annealing activity, Non-small cell lung cancer, negative regulation of cell growth, protein complex, Pancreatic cancer, Homo sapiens, chromatin binding, response to gamma radiation, protein N-terminus binding, copper ion binding, negative regulation of helicase activity, mitochondrion, Cellular tumor antigen p53, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Melanoma, Neurotrophin signaling pathway, insoluble fraction, transcription factor binding, cell cycle arrest, nucleotide-excision repair, nucleolus, Wnt signaling pathway, transcription activator activity, Amyotrophic lateral sclerosis (ALS), tumor protein p53, Prostate cancer, Small cell lung cancer, protein tetramerization, MAPK signaling pathway, Cell cycle, enzyme binding, chaperone binding, Huntington's disease, p53 signaling pathway, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, cell aging Molscript image for 2ocjD00
2.60.40.720.1.1.2.11.13 1ycsA00 Homo sapiens, chromatin binding, Pancreatic cancer, response to gamma radiation, protein N-terminus binding, mitochondrion, negative regulation of helicase activity, copper ion binding, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, Neurotrophin signaling pathway, Melanoma, cell cycle arrest, nucleotide-excision repair, nucleolus, transcription factor binding, insoluble fraction, Wnt signaling pathway, transcription activator activity, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, p53 signaling pathway, Huntington's disease, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, cell aging, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, promoter binding, Basal cell carcinoma, base-excision repair, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, protein complex Molscript image for 1ycsA00
2.60.40.720.1.1.2.11.14 1tsrB00 promoter binding, base-excision repair, Basal cell carcinoma, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, ATP binding, Thyroid cancer, Apoptosis, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Non-small cell lung cancer, negative regulation of cell growth, Colorectal cancer, Chronic myeloid leukemia, DNA strand annealing activity, protein complex, cellular response to glucose starvation, zinc ion binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, protein heterodimerization activity, activation of caspase activity by cytochrome c, ER overload response, nuclear matrix, transcription factor binding, insoluble fraction, nucleolus, cell cycle arrest, nucleotide-excision repair, Neurotrophin signaling pathway, Melanoma, transcription activator activity, Wnt signaling pathway, protein N-terminus binding, response to gamma radiation, Pancreatic cancer, Homo sapiens, chromatin binding, Cellular tumor antigen p53, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, copper ion binding, negative regulation of helicase activity, mitochondrion, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Huntington's disease, p53 signaling pathway, cell aging, Small cell lung cancer, protein tetramerization, Amyotrophic lateral sclerosis (ALS), tumor protein p53, Prostate cancer, chaperone binding, MAPK signaling pathway, Cell cycle, enzyme binding Molscript image for 1tsrB00
2.60.40.720.1.1.2.11.15 1tupB00 Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, cell aging, p53 signaling pathway, Huntington's disease, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, mitochondrion, negative regulation of helicase activity, copper ion binding, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, Homo sapiens, chromatin binding, Pancreatic cancer, protein N-terminus binding, response to gamma radiation, Wnt signaling pathway, transcription activator activity, Neurotrophin signaling pathway, Melanoma, nucleolus, cell cycle arrest, nucleotide-excision repair, insoluble fraction, transcription factor binding, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, protein complex, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Basal cell carcinoma, base-excision repair, promoter binding Molscript image for 1tupB00
2.60.40.720.1.1.2.11.16 1tsrC00 MAPK signaling pathway, Cell cycle, enzyme binding, chaperone binding, Amyotrophic lateral sclerosis (ALS), tumor protein p53, Prostate cancer, Small cell lung cancer, protein tetramerization, cell aging, Huntington's disease, p53 signaling pathway, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, copper ion binding, negative regulation of helicase activity, mitochondrion, Cellular tumor antigen p53, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Pancreatic cancer, Homo sapiens, chromatin binding, response to gamma radiation, protein N-terminus binding, Wnt signaling pathway, transcription activator activity, Melanoma, Neurotrophin signaling pathway, insoluble fraction, transcription factor binding, cell cycle arrest, nucleotide-excision repair, nucleolus, ER overload response, nuclear matrix, protein heterodimerization activity, activation of caspase activity by cytochrome c, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, cellular response to glucose starvation, zinc ion binding, protein complex, Colorectal cancer, Chronic myeloid leukemia, DNA strand annealing activity, Non-small cell lung cancer, negative regulation of cell growth, Apoptosis, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, ATP binding, Thyroid cancer, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Basal cell carcinoma, base-excision repair, promoter binding Molscript image for 1tsrC00
2.60.40.720.1.1.2.11.17 1tupC00 Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, promoter binding, Basal cell carcinoma, base-excision repair, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, protein complex, Homo sapiens, chromatin binding, Pancreatic cancer, response to gamma radiation, protein N-terminus binding, mitochondrion, negative regulation of helicase activity, copper ion binding, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, Melanoma, Neurotrophin signaling pathway, cell cycle arrest, nucleotide-excision repair, nucleolus, transcription factor binding, insoluble fraction, Wnt signaling pathway, transcription activator activity, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, p53 signaling pathway, Huntington's disease, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, cell aging Molscript image for 1tupC00
2.60.40.720.1.1.2.11.18 1tsrA00 response to gamma radiation, protein N-terminus binding, Homo sapiens, chromatin binding, Pancreatic cancer, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Cellular tumor antigen p53, mitochondrion, negative regulation of helicase activity, copper ion binding, cell cycle arrest, nucleolus, nucleotide-excision repair, transcription factor binding, insoluble fraction, Melanoma, Neurotrophin signaling pathway, transcription activator activity, Wnt signaling pathway, Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, cell aging, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, promoter binding, base-excision repair, Basal cell carcinoma, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, protein complex Molscript image for 1tsrA00
2.60.40.720.1.1.2.11.19 1tupA00 Wnt signaling pathway, transcription activator activity, Melanoma, Neurotrophin signaling pathway, nucleotide-excision repair, cell cycle arrest, nucleolus, insoluble fraction, transcription factor binding, mitochondrion, negative regulation of helicase activity, copper ion binding, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Cellular tumor antigen p53, Homo sapiens, chromatin binding, Pancreatic cancer, response to gamma radiation, protein N-terminus binding, cell aging, p53 signaling pathway, Huntington's disease, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, Basal cell carcinoma, base-excision repair, promoter binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, protein complex, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation Molscript image for 1tupA00
2.60.40.720.1.1.2.11.20 2ataC00 promoter binding, Basal cell carcinoma, base-excision repair, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Apoptosis, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, ATP binding, Thyroid cancer, Colorectal cancer, Chronic myeloid leukemia, DNA strand annealing activity, Non-small cell lung cancer, negative regulation of cell growth, protein complex, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, cellular response to glucose starvation, zinc ion binding, ER overload response, nuclear matrix, protein heterodimerization activity, activation of caspase activity by cytochrome c, Melanoma, Neurotrophin signaling pathway, transcription factor binding, insoluble fraction, nucleolus, cell cycle arrest, nucleotide-excision repair, Wnt signaling pathway, transcription activator activity, Pancreatic cancer, Homo sapiens, chromatin binding, response to gamma radiation, protein N-terminus binding, copper ion binding, negative regulation of helicase activity, mitochondrion, Cellular tumor antigen p53, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Huntington's disease, p53 signaling pathway, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, cell aging, Amyotrophic lateral sclerosis (ALS), tumor protein p53, Prostate cancer, Small cell lung cancer, protein tetramerization, MAPK signaling pathway, Cell cycle, enzyme binding, chaperone binding Molscript image for 2ataC00
2.60.40.720.1.1.2.11.21 2ataA00 Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Cellular tumor antigen p53, mitochondrion, copper ion binding, negative regulation of helicase activity, protein N-terminus binding, response to gamma radiation, Homo sapiens, chromatin binding, Pancreatic cancer, transcription activator activity, Wnt signaling pathway, nucleotide-excision repair, nucleolus, cell cycle arrest, insoluble fraction, transcription factor binding, Neurotrophin signaling pathway, Melanoma, chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), cell aging, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, base-excision repair, Basal cell carcinoma, promoter binding, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, protein complex, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer Molscript image for 2ataA00
2.60.40.720.1.1.2.11.22 2ataD00 promoter binding, base-excision repair, Basal cell carcinoma, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, protein complex, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, nucleotide-excision repair, cell cycle arrest, nucleolus, transcription factor binding, insoluble fraction, Melanoma, Neurotrophin signaling pathway, transcription activator activity, Wnt signaling pathway, protein N-terminus binding, response to gamma radiation, Homo sapiens, chromatin binding, Pancreatic cancer, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Cellular tumor antigen p53, mitochondrion, copper ion binding, negative regulation of helicase activity, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, cell aging, Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway Molscript image for 2ataD00
2.60.40.720.1.1.2.11.23 2ataB00 Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, cell aging, Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, cell cycle arrest, nucleotide-excision repair, nucleolus, transcription factor binding, insoluble fraction, Melanoma, Neurotrophin signaling pathway, transcription activator activity, Wnt signaling pathway, response to gamma radiation, protein N-terminus binding, Homo sapiens, chromatin binding, Pancreatic cancer, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, mitochondrion, copper ion binding, negative regulation of helicase activity, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, protein complex, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, promoter binding, base-excision repair, Basal cell carcinoma, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis Molscript image for 2ataB00
2.60.40.720.1.1.2.11.24 1kzyA00 Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, positive regulation of gene-specific transcription from RNA polymerase II promoter, Ras protein signal transduction, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, cell aging, response to gamma radiation, protein N-terminus binding, Homo sapiens, chromatin binding, Pancreatic cancer, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, mitochondrion, negative regulation of helicase activity, copper ion binding, cell cycle arrest, nucleotide-excision repair, nucleolus, insoluble fraction, transcription factor binding, Neurotrophin signaling pathway, Melanoma, transcription activator activity, Wnt signaling pathway, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, protein complex, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, promoter binding, base-excision repair, Basal cell carcinoma Molscript image for 1kzyA00
2.60.40.720.1.1.2.11.25 1kzyB00 base-excision repair, Basal cell carcinoma, promoter binding, Thyroid cancer, ATP binding, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, protein complex, Non-small cell lung cancer, negative regulation of cell growth, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, activation of caspase activity by cytochrome c, protein heterodimerization activity, nuclear matrix, ER overload response, zinc ion binding, cellular response to glucose starvation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, transcription activator activity, Wnt signaling pathway, cell cycle arrest, nucleotide-excision repair, nucleolus, insoluble fraction, transcription factor binding, Melanoma, Neurotrophin signaling pathway, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, mitochondrion, negative regulation of helicase activity, copper ion binding, protein N-terminus binding, response to gamma radiation, Homo sapiens, chromatin binding, Pancreatic cancer, cell aging, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, p53 signaling pathway, Huntington's disease, chaperone binding, Cell cycle, enzyme binding, MAPK signaling pathway, Small cell lung cancer, protein tetramerization, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS) Molscript image for 1kzyB00
2.60.40.720.1.1.2.11.26 2adyA00 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, protein complex, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, promoter binding, Basal cell carcinoma, base-excision repair, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, p53 signaling pathway, Huntington's disease, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Pathways in cancer, Glioma, regulation of mitochondrial membrane permeability, cell aging, Homo sapiens, chromatin binding, Pancreatic cancer, response to gamma radiation, protein N-terminus binding, mitochondrion, copper ion binding, negative regulation of helicase activity, Bladder cancer, sequence-specific DNA binding transcription factor activity, PML body, Cellular tumor antigen p53, Melanoma, Neurotrophin signaling pathway, cell cycle arrest, nucleotide-excision repair, nucleolus, insoluble fraction, transcription factor binding, Wnt signaling pathway, transcription activator activity Molscript image for 2adyA00
2.60.40.720.1.1.2.11.27 2adyB00 Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, promoter binding, Basal cell carcinoma, base-excision repair, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, protein complex, Homo sapiens, chromatin binding, Pancreatic cancer, protein N-terminus binding, response to gamma radiation, mitochondrion, negative regulation of helicase activity, copper ion binding, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Cellular tumor antigen p53, Melanoma, Neurotrophin signaling pathway, nucleolus, nucleotide-excision repair, cell cycle arrest, transcription factor binding, insoluble fraction, Wnt signaling pathway, transcription activator activity, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, p53 signaling pathway, Huntington's disease, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, cell aging Molscript image for 2adyB00
2.60.40.720.1.1.2.11.28 2fejA00 Chronic myeloid leukemia, DNA strand annealing activity, Colorectal cancer, Non-small cell lung cancer, negative regulation of cell growth, protein complex, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, zinc ion binding, cellular response to glucose starvation, nuclear matrix, ER overload response, activation of caspase activity by cytochrome c, protein heterodimerization activity, promoter binding, Basal cell carcinoma, base-excision repair, Endometrial cancer, mitotic cell cycle G1/S transition DNA damage checkpoint, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, Apoptosis, Thyroid cancer, ATP binding, p53 signaling pathway, Huntington's disease, Ras protein signal transduction, positive regulation of gene-specific transcription from RNA polymerase II promoter, Glioma, Pathways in cancer, regulation of mitochondrial membrane permeability, cell aging, tumor protein p53, Prostate cancer, Amyotrophic lateral sclerosis (ALS), Small cell lung cancer, protein tetramerization, Cell cycle, enzyme binding, MAPK signaling pathway, chaperone binding, Neurotrophin signaling pathway, Melanoma, nucleotide-excision repair, cell cycle arrest, nucleolus, transcription factor binding, insoluble fraction, Wnt signaling pathway, transcription activator activity, Homo sapiens, chromatin binding, Pancreatic cancer, protein N-terminus binding, response to gamma radiation, mitochondrion, copper ion binding, negative regulation of helicase activity, Bladder cancer, PML body, sequence-specific DNA binding transcription factor activity, Cellular tumor antigen p53 Molscript image for 2fejA00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages: