S100 Family: 2.60.40.320.3.1.1.1

Representative domain: 3hn3A02

Classification Lineage (2.60.40.320.3.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.60	Sandwich
2.60.40	Immunoglobulin-like
2.60.40.320		Gene3D
2.60.40.320.3
2.60.40.320.3.1
2.60.40.320.3.1.1
2.60.40.320.3.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	6

Non-Redundant Representatives (6)
Structural Neighbours ()
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.60.40.320.3.1.1.1 (6)

CATH code	Domain ID	Keywords
2.60.40.320.3.1.1.1.1	3hn3A02	Beta-glucuronidase., beta-glucuronidase activity, Beta-glucuronidase, Drug metabolism - other enzymes, beta-glucuronidase [EC:3.2.1.31], Porphyrin and chlorophyll metabolism, Pentose and glucuronate interconversions, Homo sapiens, Glycosaminoglycan degradation, Metabolic pathways, Starch and sucrose metabolism, glycosaminoglycan catabolic process, Lysosome
2.60.40.320.3.1.1.1.2	3hn3B02	Beta-glucuronidase, Drug metabolism - other enzymes, Porphyrin and chlorophyll metabolism, beta-glucuronidase [EC:3.2.1.31], Beta-glucuronidase., beta-glucuronidase activity, Metabolic pathways, Starch and sucrose metabolism, glycosaminoglycan catabolic process, Lysosome, Pentose and glucuronate interconversions, Homo sapiens, Glycosaminoglycan degradation
2.60.40.320.3.1.1.1.3	3hn3D02	Beta-glucuronidase., beta-glucuronidase activity, Beta-glucuronidase, Drug metabolism - other enzymes, beta-glucuronidase [EC:3.2.1.31], Porphyrin and chlorophyll metabolism, Pentose and glucuronate interconversions, Homo sapiens, Glycosaminoglycan degradation, Starch and sucrose metabolism, Metabolic pathways, glycosaminoglycan catabolic process, Lysosome
2.60.40.320.3.1.1.1.4	3hn3E02	Beta-glucuronidase, Drug metabolism - other enzymes, beta-glucuronidase [EC:3.2.1.31], Porphyrin and chlorophyll metabolism, Beta-glucuronidase., beta-glucuronidase activity, Starch and sucrose metabolism, Metabolic pathways, glycosaminoglycan catabolic process, Lysosome, Pentose and glucuronate interconversions, Homo sapiens, Glycosaminoglycan degradation
2.60.40.320.3.1.1.1.5	1bhgA02	glycosaminoglycan catabolic process, Lysosome, Metabolic pathways, Starch and sucrose metabolism, Glycosaminoglycan degradation, Pentose and glucuronate interconversions, Homo sapiens, Drug metabolism - other enzymes, beta-glucuronidase [EC:3.2.1.31], Porphyrin and chlorophyll metabolism, Beta-glucuronidase, beta-glucuronidase activity, Beta-glucuronidase.
2.60.40.320.3.1.1.1.6	1bhgB02	Glycosaminoglycan degradation, Pentose and glucuronate interconversions, Homo sapiens, Lysosome, glycosaminoglycan catabolic process, Metabolic pathways, Starch and sucrose metabolism, beta-glucuronidase activity, Beta-glucuronidase., Porphyrin and chlorophyll metabolism, beta-glucuronidase [EC:3.2.1.31], Drug metabolism - other enzymes, Beta-glucuronidase

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Comparisons for Non-redundant S35 Representatives of 2.60.40.320.3.1.1.1 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

S100 Family: 2.60.40.320.3.1.1.1

Classification Lineage (2.60.40.320.3.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.60.40.320.3.1.1.1 (6)

What is a Structural Neighbour?

Structural Comparisons for Non-redundant S35 Representatives of 2.60.40.320.3.1.1.1 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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