S100 Family: 2.40.10.10.8.1.5.1

Representative domain: 3fp7E02

Classification Lineage (2.40.10.10.8.1.5.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.10	Thrombin, subunit H
2.40.10.10	Trypsin-like serine proteases	Gene3D
2.40.10.10.8
2.40.10.10.8.1
2.40.10.10.8.1.5
2.40.10.10.8.1.5.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	27

Non-Redundant Representatives (27)
Structural Neighbours ()
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.40.10.10.8.1.5.1 (27)

CATH code	Domain ID	Keywords
2.40.10.10.8.1.5.1.1	3fp7E02	Rattus norvegicus, trypsin [EC:3.4.21.4], digestion, Neuroactive ligand-receptor interaction, Anionic trypsin-2, Trypsin., response to nutrient
2.40.10.10.8.1.5.1.2	3fp8E02	response to nutrient, Trypsin., Anionic trypsin-2, digestion, Neuroactive ligand-receptor interaction, trypsin [EC:3.4.21.4], Rattus norvegicus
2.40.10.10.8.1.5.1.3	3fp6E02	Trypsin., Anionic trypsin-2, response to nutrient, Rattus norvegicus, digestion, Neuroactive ligand-receptor interaction, trypsin [EC:3.4.21.4]
2.40.10.10.8.1.5.1.4	1f7zA02	Anionic trypsin-2, Trypsin., response to nutrient, Rattus norvegicus, trypsin [EC:3.4.21.4], digestion, Neuroactive ligand-receptor interaction
2.40.10.10.8.1.5.1.5	1dpoA02	Anionic trypsin-2, Trypsin., response to nutrient, Rattus norvegicus, trypsin [EC:3.4.21.4], digestion, Neuroactive ligand-receptor interaction
2.40.10.10.8.1.5.1.6	1f5rA02	Anionic trypsin-2, Trypsin., response to nutrient, Rattus norvegicus, trypsin [EC:3.4.21.4], digestion, Neuroactive ligand-receptor interaction
2.40.10.10.8.1.5.1.7	1fy8E02	trypsin [EC:3.4.21.4], Neuroactive ligand-receptor interaction, digestion, Rattus norvegicus, response to nutrient, Anionic trypsin-2, Trypsin.
2.40.10.10.8.1.5.1.8	1yktA02	response to nutrient, Trypsin., Anionic trypsin-2, digestion, Neuroactive ligand-receptor interaction, trypsin [EC:3.4.21.4], Rattus norvegicus
2.40.10.10.8.1.5.1.9	1ylcA02	Rattus norvegicus, Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Trypsin., Anionic trypsin-2, response to nutrient
2.40.10.10.8.1.5.1.10	1yldA02	Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Rattus norvegicus, response to nutrient, Trypsin., Anionic trypsin-2
2.40.10.10.8.1.5.1.11	3tgkE02	response to nutrient, Trypsin., Anionic trypsin-2, Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Rattus norvegicus
2.40.10.10.8.1.5.1.12	3tgiE02	Rattus norvegicus, digestion, Neuroactive ligand-receptor interaction, trypsin [EC:3.4.21.4], Trypsin., Anionic trypsin-2, response to nutrient
2.40.10.10.8.1.5.1.13	1sluB02	Rattus norvegicus, trypsin [EC:3.4.21.4], digestion, Neuroactive ligand-receptor interaction, Anionic trypsin-2, Trypsin., response to nutrient
2.40.10.10.8.1.5.1.14	1brbE02	Trypsin., Anionic trypsin-2, response to nutrient, Rattus norvegicus, Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4]
2.40.10.10.8.1.5.1.15	1slwB02	Trypsin., Anionic trypsin-2, response to nutrient, Rattus norvegicus, Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4]
2.40.10.10.8.1.5.1.16	1ancA02	Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Rattus norvegicus, response to nutrient, Trypsin., Anionic trypsin-2
2.40.10.10.8.1.5.1.17	1aneA02	Rattus norvegicus, trypsin [EC:3.4.21.4], digestion, Neuroactive ligand-receptor interaction, Anionic trypsin-2, Trypsin., response to nutrient
2.40.10.10.8.1.5.1.18	1braA02	Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Rattus norvegicus, response to nutrient, Trypsin., Anionic trypsin-2
2.40.10.10.8.1.5.1.19	3tgjE02	Rattus norvegicus, Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Trypsin., Anionic trypsin-2, response to nutrient
2.40.10.10.8.1.5.1.20	1k9oE02	digestion, Neuroactive ligand-receptor interaction, trypsin [EC:3.4.21.4], Rattus norvegicus, response to nutrient, Trypsin., Anionic trypsin-2
2.40.10.10.8.1.5.1.21	1slxB02	response to nutrient, Trypsin., Anionic trypsin-2, Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Rattus norvegicus
2.40.10.10.8.1.5.1.22	1slvB02	Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Rattus norvegicus, response to nutrient, Trypsin., Anionic trypsin-2
2.40.10.10.8.1.5.1.23	1amhA02	Rattus norvegicus, trypsin [EC:3.4.21.4], Neuroactive ligand-receptor interaction, digestion, Anionic trypsin-2, Trypsin., response to nutrient
2.40.10.10.8.1.5.1.24	1amhB02	Neuroactive ligand-receptor interaction, digestion, trypsin [EC:3.4.21.4], Rattus norvegicus, response to nutrient, Trypsin., Anionic trypsin-2
2.40.10.10.8.1.5.1.25	1brcE02	digestion, Neuroactive ligand-receptor interaction, trypsin [EC:3.4.21.4], Rattus norvegicus, response to nutrient, Trypsin., Anionic trypsin-2
2.40.10.10.8.1.5.1.26	1anbA02	Anionic trypsin-2, Trypsin., response to nutrient, Rattus norvegicus, trypsin [EC:3.4.21.4], Neuroactive ligand-receptor interaction, digestion
2.40.10.10.8.1.5.1.27	1i99E02

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Comparisons for Non-redundant S35 Representatives of 2.40.10.10.8.1.5.1 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

S100 Family: 2.40.10.10.8.1.5.1

Classification Lineage (2.40.10.10.8.1.5.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.40.10.10.8.1.5.1 (27)

What is a Structural Neighbour?

Structural Comparisons for Non-redundant S35 Representatives of 2.40.10.10.8.1.5.1 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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