S100 Family: 2.40.10.10.15.1.1.1

Representative domain: 1gvkB01

Classification Lineage (2.40.10.10.15.1.1.1)

CATH Code	Level Description	Links
2	Mainly Beta
2.40	Beta Barrel
2.40.10	Thrombin, subunit H
2.40.10.10	Trypsin-like serine proteases	Gene3D
2.40.10.10.15
2.40.10.10.15.1
2.40.10.10.15.1.1
2.40.10.10.15.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	96

Non-Redundant Representatives (96)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 2.40.10.10.15.1.1.1 (96)

CATH code	Domain ID	Keywords
2.40.10.10.15.1.1.1.1	1gvkB01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.2	3hgpA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.3	1qnjA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.4	2de9A01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.5	2bloA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.6	2blqA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.7	1hazB01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.8	1l0zA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.9	1l1gA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.10	2de8A01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.11	1btuA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.12	1qr3E01
2.40.10.10.15.1.1.1.13	2bb4A01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.14	2bd3A01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.15	2bd7A01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.16	2h1uA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.17	2iotA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.18	3e3tA01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.19	1elgA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.20	1esaA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.21	1nesE01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.22	1uo6A01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.23	2a7cA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.24	2a7jA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.25	2v0bA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.26	3estA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.27	3hgnA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.28	1h9lB01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.29	2v35A01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.30	1e36B01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.31	1e38B01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.32	1elfA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.33	1hv7A01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.34	1lkaA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.35	1lkbA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.36	1qgfA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.37	2bd2A01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.38	2bd4A01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.39	2bd8A01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.40	2bdbA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.41	1e37B01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.42	1elcA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.43	4estE01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.44	8estE01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.45	1b0eA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.46	1bmaA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.47	1e34B01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.48	1easA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.49	1mcvA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.50	2bd5A01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.51	2bdaA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.52	2bdcA01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.53	2fohA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.54	2oquA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.55	6estA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.56	7estE01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.57	2g4uA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.58	1gwaA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.59	1uvoA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.60	1uvpA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.61	1fzzA01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.62	1lvyA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.63	1e35B01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.64	1fleE01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.65	1qixB01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.66	2bd9A01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.67	2cv3A01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.68	2foaA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.69	2fobA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.70	2fogA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.71	9estA01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.72	1incA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.73	1eatA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.74	1eauA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.75	1elaA01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.76	1eldE01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.77	1eleE01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.78	2fo9A01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.79	2focA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.80	2fodA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.81	5estE01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.82	1elbA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.83	2g4tA01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.84	1c1mA01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.85	1mmjN01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.86	2foeA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.87	2fofA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.88	1esbA01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.89	1jimA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.90	1eaiA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.91	1eaiB01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.92	1estA01	protein binding, Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase.
2.40.10.10.15.1.1.1.93	2estE01	Sus scrofa, Chymotrypsin-like elastase family member 1, Pancreatic elastase., protein binding
2.40.10.10.15.1.1.1.94	1okxA01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding
2.40.10.10.15.1.1.1.95	1okxB01	protein binding, Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1
2.40.10.10.15.1.1.1.96	2d26C01	Pancreatic elastase., Sus scrofa, Chymotrypsin-like elastase family member 1, protein binding

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.40.10.10.15.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 2.40.10.10.15.1.1.1

Classification Lineage (2.40.10.10.15.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 2.40.10.10.15.1.1.1 (96)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts