S100 Family: 2.30.30.40.8.1.2.1

Molscript image for 1opkA01
Representative domain: 1opkA01
PDB coordinates for domain 1opkA01

Classification Lineage (2.30.30.40.8.1.2.1)

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.8
2.30.30.40.8.1
2.30.30.40.8.1.2
2.30.30.40.8.1.2.1

Summary of Non-Redundant Representatives
- - - - - - - - 6

S100 Count Entries in S100 Family 2.30.30.40.8.1.2.1 (6)

CATH Level CATH code Domain ID Keywords Thumbnail
2.30.30.40.8.1.2.1.1 1opkA01 peptidyl-tyrosine phosphorylation, protein domain specific binding, Mus musculus, Non-specific protein-tyrosine kinase., magnesium ion binding, Tyrosine-protein kinase ABL1, manganese ion binding, actin cytoskeleton organization, ATP binding, nucleus, regulation of cell cycle Molscript image for 1opkA01
2.30.30.40.8.1.2.1.2 1bbzA00 ATP binding, positive regulation of oxidoreductase activity, Tyrosine-protein kinase ABL1, perinuclear region of cytoplasm, manganese ion binding, Axon guidance, Chronic myeloid leukemia, proto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2], Homo sapiens, peptidyl-tyrosine phosphorylation, nucleolus, Neurotrophin signaling pathway, Pathogenic Escherichia coli infection, DNA damage response, signal transduction resulting in induction of apoptosis, Cell cycle, magnesium ion binding, protein C-terminus binding, mismatch repair, Non-specific protein-tyrosine kinase., Pathways in cancer, ErbB signaling pathway, Viral myocarditis, regulation of transcription involved in S phase of mitotic cell cycle Molscript image for 1bbzA00
2.30.30.40.8.1.2.1.3 1bbzC00 Axon guidance, Chronic myeloid leukemia, manganese ion binding, Tyrosine-protein kinase ABL1, perinuclear region of cytoplasm, ATP binding, positive regulation of oxidoreductase activity, Non-specific protein-tyrosine kinase., mismatch repair, regulation of transcription involved in S phase of mitotic cell cycle, Pathways in cancer, Viral myocarditis, ErbB signaling pathway, Cell cycle, Pathogenic Escherichia coli infection, DNA damage response, signal transduction resulting in induction of apoptosis, magnesium ion binding, protein C-terminus binding, Neurotrophin signaling pathway, peptidyl-tyrosine phosphorylation, nucleolus, Homo sapiens, proto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2] Molscript image for 1bbzC00
2.30.30.40.8.1.2.1.4 1bbzE00 ATP binding, positive regulation of oxidoreductase activity, manganese ion binding, Tyrosine-protein kinase ABL1, perinuclear region of cytoplasm, Axon guidance, Chronic myeloid leukemia, Homo sapiens, proto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2], Neurotrophin signaling pathway, peptidyl-tyrosine phosphorylation, nucleolus, Cell cycle, Pathogenic Escherichia coli infection, DNA damage response, signal transduction resulting in induction of apoptosis, protein C-terminus binding, magnesium ion binding, Non-specific protein-tyrosine kinase., mismatch repair, regulation of transcription involved in S phase of mitotic cell cycle, Pathways in cancer, Viral myocarditis, ErbB signaling pathway Molscript image for 1bbzE00
2.30.30.40.8.1.2.1.5 1bbzG00 nucleolus, peptidyl-tyrosine phosphorylation, Neurotrophin signaling pathway, proto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2], Homo sapiens, Viral myocarditis, ErbB signaling pathway, Pathways in cancer, regulation of transcription involved in S phase of mitotic cell cycle, mismatch repair, Non-specific protein-tyrosine kinase., protein C-terminus binding, magnesium ion binding, DNA damage response, signal transduction resulting in induction of apoptosis, Pathogenic Escherichia coli infection, Cell cycle, Tyrosine-protein kinase ABL1, perinuclear region of cytoplasm, manganese ion binding, positive regulation of oxidoreductase activity, ATP binding, Chronic myeloid leukemia, Axon guidance Molscript image for 1bbzG00
2.30.30.40.8.1.2.1.6 1oplA01 Chronic myeloid leukemia, Axon guidance, positive regulation of oxidoreductase activity, ATP binding, Tyrosine-protein kinase ABL1, perinuclear region of cytoplasm, manganese ion binding, magnesium ion binding, protein C-terminus binding, Pathogenic Escherichia coli infection, DNA damage response, signal transduction resulting in induction of apoptosis, Cell cycle, Pathways in cancer, Viral myocarditis, ErbB signaling pathway, regulation of transcription involved in S phase of mitotic cell cycle, mismatch repair, Non-specific protein-tyrosine kinase., proto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2], Homo sapiens, peptidyl-tyrosine phosphorylation, nucleolus, Neurotrophin signaling pathway Molscript image for 1oplA01

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:
  • Multiple alignments for each functional family
  • Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
  • Detailed functional information on diversity and conservation within Functional families
  • Multi-domain architectures
In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:
http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=2.30.30.40.8.1.2.1