S100 Family: 1.10.340.30.5.1.1.1

Representative domain: 1mpgA02

Classification Lineage (1.10.340.30.5.1.1.1)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.340	Endonuclease III; domain 1
1.10.340.30	Hypothetical protein; domain 2	Gene3D
1.10.340.30.5
1.10.340.30.5.1
1.10.340.30.5.1.1
1.10.340.30.5.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	38

Non-Redundant Representatives (38)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 1.10.340.30.5.1.1.1 (38)

CATH code	Domain ID	Keywords
1.10.340.30.5.1.1.1.1	1mpgA02	cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.2	1mpgB02	DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.340.30.5.1.1.1.3	3cw7A02	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair
1.10.340.30.5.1.1.1.4	3cw7B02	cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.5	3cw7C02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.6	3cw7D02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.7	3cwsA02	DNA-3-methyladenine glycosylase 2, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.340.30.5.1.1.1.8	3cwsB02	DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity
1.10.340.30.5.1.1.1.9	3cwsC02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.10	3cwsD02	DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair
1.10.340.30.5.1.1.1.11	3cwtA02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.12	3cwtB02	DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity
1.10.340.30.5.1.1.1.13	3cwtC02	DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm
1.10.340.30.5.1.1.1.14	3cwtD02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, base-excision repair, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.15	1pvsA02	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair
1.10.340.30.5.1.1.1.16	1pvsB02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.17	3cvsA02	DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity
1.10.340.30.5.1.1.1.18	3cvsB02	base-excision repair, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], DNA-3-methyladenine glycosylase 2, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II.
1.10.340.30.5.1.1.1.19	3cvsC02	DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, base-excision repair, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.340.30.5.1.1.1.20	3cvsD02	DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, base-excision repair, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.340.30.5.1.1.1.21	3cwaA02	cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.22	3cwaB02	base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding
1.10.340.30.5.1.1.1.23	3cwaC02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, base-excision repair, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.24	3cwaD02	DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity
1.10.340.30.5.1.1.1.25	1dizA02	alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.26	1dizB02	Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair
1.10.340.30.5.1.1.1.27	3cvtA02	DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, base-excision repair
1.10.340.30.5.1.1.1.28	3cvtB02	DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.340.30.5.1.1.1.29	3cvtC02	DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.340.30.5.1.1.1.30	3cvtD02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, base-excision repair, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.31	3cwuA02	base-excision repair, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], DNA-3-methyladenine glycosylase 2, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II.
1.10.340.30.5.1.1.1.32	3cwuB02	base-excision repair, alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], DNA-3-methyladenine glycosylase 2, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II.
1.10.340.30.5.1.1.1.33	3cwuC02	Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair
1.10.340.30.5.1.1.1.34	3cwuD02	DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase 2, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair
1.10.340.30.5.1.1.1.35	3d4vA02	DNA-3-methyladenine glycosylase 2, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., Escherichia coli K-12, Base excision repair, protein binding, base-excision repair, cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
1.10.340.30.5.1.1.1.36	3d4vB02	cytoplasm, alkylbase DNA N-glycosylase activity, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], base-excision repair, Escherichia coli K-12, Base excision repair, protein binding, DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase II., DNA-3-methyladenine glycosylase 2
1.10.340.30.5.1.1.1.37	3d4vC02	base-excision repair, DNA-3-methyladenine glycosylase II [EC:3.2.2.21], alkylbase DNA N-glycosylase activity, cytoplasm, DNA-3-methyladenine glycosylase 2, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair
1.10.340.30.5.1.1.1.38	3d4vD02	DNA-3-methyladenine glycosylase II [EC:3.2.2.21], cytoplasm, alkylbase DNA N-glycosylase activity, base-excision repair, Base excision repair, protein binding, Escherichia coli K-12, DNA-3-methyladenine glycosylase II., DNA dealkylation involved in DNA repair, DNA-3-methyladenine glycosylase 2

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=1.10.340.30.5.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 1.10.340.30.5.1.1.1

Classification Lineage (1.10.340.30.5.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 1.10.340.30.5.1.1.1 (38)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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